SHIRE PHARMACEUTICALS GROUP: Encargos

All obligations (monetary or otherwise ) of the company to the chargee arising under or in connection with the amended and restated credit agreement dated 19TH november 1999, any interest rate swap,cap,collar or similar agreement entered into pursuant to the terms of the credit agreement, any promissory note payable to any lender under the credit agreement evidencing the agrregate indebtedness to any such lender ,any standby or commercial letters of credit any loan request any letter of credit request,the letter dated 19TH november 199 and any agreements defined therein

All monies due or to become due from shire pharmaceutical development limited to the noteholders (as defined) in respect of the £10,000,000 10% fixed rate secured loan notes of 1995 of spdl originally constituted by the deed poll of spdl dated 1994 or under the terms of the loan note instrument and all reasonable costs,charges and expenses incurred under or in respect of the debenture by the instructing group (as defined) or by the noteholders or by any receiver appointed under the debenture